Dev108043 3370..3377
نویسنده
چکیده
The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial
منابع مشابه
Effects of hybrid and ensiling with and without a microbial inoculant on the nutritional characteristics of whole-plant corn.
Two corn hybrids (Pioneer 3377 and 3389) with similar total plant and grain yield characteristics were evaluated to determine potential differences in nutritive value of the whole plant and stover. Hybrids were grown in plots at four different locations in Idaho in 1988 and 1989 for laboratory evaluation. Samples from the plots were stored fresh or ensiled with or without a microbial inoculant ...
متن کاملAllergic contact dermatitis in child with odontoiatric face-mask.
Corresponding author Antonella Tammaro Dermatology Unit, NESMOS Department, S. Andrea Hospital, University of Rome “Sapienza” Via di Grottarossa, 1035 00189 Rome (RM), Italy Phone: +39 06 3377 5907 Fax: +39 06 3377 5378 E-mail: [email protected]
متن کاملThe Mass Distribution in the Elliptical Galaxy Ngc 3377 : Evidence for a 2 108 - M
This paper is a study of the mass distribution in the central 35 00 ' 1.7 kpc of the E5 galaxy NGC 3377. Stellar rotation velocity and velocity dispersion prooles (seeing = 0. 00 20 { 0. 00 56) and V-band surface photometry (= 0. 00 20 { 0. 00 26) have been obtained with the Canada-France-Hawaii Telescope. NGC 3377 is kinematically similar to M 32: the central kinematic gradients are steep. The...
متن کاملCustom Specializers in Object-Oriented Lisp
We describe in this paper the implementation and use of custom specializers in two current dialects of Lisp: Skill and Common Lisp. We motivate the need for such specializers by appealing to clarity of expression, referring to experience in existing industrial applications. We discuss the implementation details of such user-defined specializers in both dialects of Lisp, detailing open problems ...
متن کاملThe Mass Distribution in the Elliptical Galaxy Ngc 3377: Evidence for a 2× 10-m⊙ Black Hole
This paper is a study of the mass distribution in the central 35 ≃ 1.7 kpc of the E5 galaxy NGC 3377. Stellar rotation velocity and velocity dispersion profiles (seeing σ∗ = 0. 20 – 0. 56) and V -band surface photometry (σ∗ = 0. 20 – 0. 26) have been obtained with the Canada-France-Hawaii Telescope. NGC 3377 is kinematically similar to M32: the central kinematic gradients are steep. There is an...
متن کامل